Principal Scientist (protein expression systems)

Principal Scientist (2-year contract)

Our client is seeking a dynamic and passionate senior scientist to join a multidisciplinary team.

Role Overview:

As a Principal Scientist, you will spearhead our upstream process development for recombinant protein production. This is a fantastic opportunity to influence both scientific direction and team growth over a 24-month contract.

Key Responsibilities:

• Lead the charge in upstream process development, focusing on recombinant protein production.
• Provide scientific leadership and technical guidance to team members and project teams.
• Translate expression optimisation from shake flasks to bioreactors as the technical lead.
• Design and refine expression methods to enhance protein quality.
• Investigate how expression conditions affect protein quality attributes across key projects.
• Collaborate across functions to drive overall process improvements.
• Champion optimisations in upstream processes using a data-led approach.
• Ensure compliance with company HSE policies while working safely.

Essential Qualifications:

• Post Doc or equivalent experience in Biotechnology, Microbiology, or related disciplines.
• 8+ years of hands-on experience in upstream bioprocessing with expertise in:

- Recombinant protein expression (bacterial, insect, yeast, or plant systems).
- Working with bioreactors and transferring shake flask processes into bioreactors.
- Protein purification methods and techniques.

• Strong troubleshooting and innovative problem-solving abilities.
• Comprehensive understanding of how upstream decisions impact downstream processing outcomes.
• Excellent communication skills to present complex concepts clearly.

Desirable Experience:

• Knowledge of construct design and its impact on protein expression.
• Familiarity with AI tools for experimental design.
• Experience with Ambr250 micro bioreactor systems.
• Background in protein characterisation to validate protein quality.
• Experience with scalable bioprocess technologies, such as Tangential Flow Filtration (TFF).
• Industry experience in Biopharma, AgriTech, or related sectors.

Why Join them?

At their organisation, you'll not only be part of an innovative team but also enjoy a range of fantastic perks:

• On-the-job training to enhance your skills.
• A large campus environment fostering collaboration.
• Excellent onsite facilities, including a site restaurant, gym, and a variety of fitness classes.