Senior Scientist (Bioscience - Translational Biology)

Senior Scientist (Bioscience - Translational Biology) £41,700 - £51,300 plus benefits

Reports to: Principal Scientist
Directorate: Research & Innovation
Contract: Permanent
Hours: Full time 35 hours per week
Location: Babraham Research Campus, Cambridge (Lab Based - Low flex with a minimum of 3 days per week on-site)

Closing date: Sunday 23rd August 23:55pm

Visa sponsorship: Cancer Research UK can consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application.

Key Duties and Responsibilities

• Lead translational assay development, linking preclinical findings to clinical relevance
• Apply human tumour biopsy tissue, patient-derived material, and primary cells in drug discovery to integrate in vitro, ex vivo, and in vivo data and support project decision making
• Design, execute, and interpret in vivo PK/PD and efficacy study (CDX, PDX) for small molecules or mAb, ADC programmes
• Design, perform complex cell culture, including 3D coculture experiments using patient-derived materials
• Conduct and interpret phenotypic analysis in cancer and immune cells including cell proliferation, apoptosis, colony formation
• Review and critically appraise published and unpublished research to identify protocols for translational assay development
• Demonstrate strong problem solving skills, ability to develop innovative solutions independently, and adapt effectively to rapidly changing drug discovery environment
• Work collaboratively within the Bioscience team and interact with multi-disciplinary research teams both internally and with external collaborators
• Communicate efficiently, interpret and summarise data and present them to different audiences
• Prioritise work according to project goals and take responsibility for the timely delivery of his/her objectives
• Maintain accurate and up to date electronic laboratory notebook
• Maintain assigned laboratory equipment and/or duties
• Perform all work demonstrating due care and attention to all health and safety regulations
• Keep up to date with state of the art technologies and knowledge of developments in cancer therapeutics with particular focus on translational model development
• Highly committed, enthusiastic with a passion for learning

Key Technical Skills, Knowledge and Experience

• PhD or equivalent in a biological science
• Postdoctoral experience (or equivalent) in oncology and/or immunology research
• Expertise in ex vivo translational models, particularly with patient derived materials, human tumour biopsies, and/or MPS (microphysiological system) and NAM approaches (desirable but not essential)
• Proven scientific leadership, with the ability to drive projects and influence research direction
• Industry research experience within pharma or biotech environments
• Strong knowledge of cell culture techniques, including coculture, primary cell handling, maintenance and optimisation
• Hands on experience with phenotypic assays, such as cell proliferation, apoptosis and colony-forming assays

Our organisation values

• Bold: Act with ambition, courage and determination
• Credible: Act with rigour and professionalism
• Human: Act to have a positive impact on people
• Together: Act inclusively and collaboratively

Benefits

What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. You can explore our benefits by visiting our careers web page.

Equality, Diversity and Inclusion

We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under represented. We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen.

Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.

Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We're the world's leading cancer charity, dedicated to saving and improving lives with our research. We work to reduce the impact of cancer on people's day-to-day lives through our research, influence and information. We are beating cancer - step by step, day by day. Find a purposeful career that will empower you to grow and collaborate with like-minded experts.