Senior Clinical Research Fellow

The UCL Huntington's Disease Centre, based in the Department of Neurodegenerative Disease at the UCL Queen Square Institute of Neurology, is led by Professor Sarah Tabrizi (Director) and Professor Gillian Bates (Co Director). Established in 2015 in a purpose built environment, the Centre brings together laboratory based mechanistic research and clinical neuroscience to enable the translation of fundamental discoveries into early phase, first in human studies. The Centre integrates preclinical research, biomarker development and clinical trial delivery, including proof of concept studies conducted through the Leonard Wolfson Experimental Neurology Centre, ahead of larger multi centre phase II and III clinical trials.

About the role

You will primarily support the clinical development aims of a range of antisense oligonucleotide, gene therapy, and small molecule huntingtin lowering trials led by Professor Sarah Tabrizi at the UCL Huntington's Disease Centre in collaboration with UCLH and the Leonard Wolfson Experimental Neurology Centre (LWENC). Acting as Chief Sub Investigator you will lead on the day to day management of all clinical trials led by Professor Tabrizi.

Key responsibilities include training and supervision of Clinical Research Fellows working on the trials, providing information to patients about the studies ensuring informed consent is obtained from participants, performing clinical and neurological assessments in accordance with Good Clinical Practice (GCP), completing case report forms in accordance with study protocols, and responding to data queries and feedback from study monitoring. You will also perform lumbar punctures and associated procedures for cerebrospinal fluid (CSF) collection, as well as procedures relating to the intrathecal drug administration, and providing rare out of hours medical care/advice for trial participants. You will also participate in the multidisciplinary HD and neurogenetics clinics at the NHNN.

An honorary contract will be sought from UCLH NHS Foundation Trust, for which a DBS check will be required.

The post is available to start from 03 August 2026 and is supported by philanthropic funding for two years in the first instance.

There may be the possibility for a successful candidate that has their CCT to apply for a future Honorary Consultant appointment at UCLH NHNN, with concomitant NHS responsibilities, subject to NHS eligibility requirements and a successful Honorary Consultant interview process.

About you

You'll be a registered medical practitioner permitted to practise in the UK, will have completed general medical training to ST6 or equivalent level, and have experience of working in Neurology and an interest in Huntington's disease. Substantial experience of working in Huntington's disease clinical trials, in depth knowledge of GCP and clinical trial governance, and demonstrable experience and proficiency in lumbar puncture are also essential for this role.

This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa.

What we offer

The role is offered in the range of £62,075 - £78,670 per annum including London Allowance, on the CL, RDPS, or StR scale, dependent on NHS contract and/or stage of clinical training.

As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days' annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• On site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service

We will consider applications to work on a part time, flexible, and job share basis wherever possible.

Our commitment to Equality, Diversity and Inclusion

The Institute prides itself on operating in an all inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visitour EDI website for more information about our initiatives and priorities. The Institute also holds an Athena SWAN Gold award, in recognition of our commitment and demonstrable impact in advancing gender equality.

As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.

We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.