Senior 3D Modelling Scientist - Hybrid & Flexible

Senior or Principal Scientist - 3D Molecular Modelling

Founded in 2009 and headquartered in Cambridge, UK, Optibrium develops software and novel technologies to improve the efficiency and productivity of drug discovery. Our solutions support industry-leading research for a global customer base, including top ten pharma and innovative biotech companies.

Optibrium software solutions include:

• StarDrop - A complete package of fully integrated software for multi-objective small molecule design, optimisation, and data analysis;
• Cerella - A unique platform for the imputation of drug discovery data, revealing insights into the best compounds and most valuable experiments;
• BioPharmics - A fast, robust, and accurate 3D ligand- and structure-based design platform that scales from small molecules to large macrocycles.

With a strong track record of translating peer reviewed science into successful products and a growing blue chip customer base for BioPharmics, we are recruiting a Senior or Principal Scientist - 3D Molecular Modelling to help customers achieve challenging drug discovery objectives and maximise the value of our software.

About the Role

As a Senior or Principal Scientist you will:

• Apply 3D structure based and ligand based design approaches to lead discovery and optimisation
• Support current and prospective customers in the effective use of BioPharmics, working with the commercial team to communicate its value clearly and scientifically
• Use NMR and X ray crystallography data in combination with the BioPharmics modelling methods
• Provide guidance on the development of the BioPharmics platform by identifying unmet customer needs and translating them into product and research opportunities
• Represent Optibrium's science and products at conferences, workshops, and customer meetings

About You

The ideal candidate will have the following experience:

• PhD in computational chemistry, computer science, chemistry, biophysics, or a related discipline
• Strong understanding of structure based and ligand based drug design, ideally including experience with macrocycles and peptides
• Experience with molecular modelling and visualisation platforms, e.g., PyMOL and MOE
• Experience with structural data (NMR and X ray crystallography) applied to molecular design problems
• A track record of high quality peer reviewed publications and conference presentations
• The ability to work effectively with customers, collaborators, and cross functional teams

What We Offer

We offer hybrid & flexible working, a competitive base salary, pension contribution, employee private medical and dental cover, life assurance, corporate gym discount and cycle to work scheme.