Principal Scientist (Functional Genomics)

. Principal Scientist - Functional Genomics annum (dependent on experience) plus Reports to: Group leader Directorate: Research & Innovation Contract: Permanent Hours: Full time 35 hours per week Location: Cambridge, UK, joint AstraZeneca - CRUK Functional Genomics Centre, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA (Lab based low-flex, with a minimum of 3 days per week on-site). Closing date: Sunday 9th August :55pm Recruitment process: Initial Teams call followed by in person interview in Cambridge, which will include competency based and technical questions with a presentation assessment. Interview date: First stage approximately w/c 17th August.We have an exciting opportunity at Cancer Research Horizons for a skilled Principal scientist to join the Joint AstraZeneca-Cancer Research Horizons Functional Genomics Centre based in Cambridge.This role offers the unique opportunity to be part of an exciting team, operating at the forefront of research and technology development, gaining experience across the breadth of CRISPR technologies whilst it is being applied to clinically actionable programs. Working in a diverse, dynamic, and cutting-edge scientific environment, this laboratory-based role will give you the opportunity to apply your molecular and cell biology and drug discovery expertise to build new capabilities and support our functional genomic screening efforts.Cancer Research Horizons (CRH) is CRUK's internal translation engine. CRUK's established drug discovery teams operate under one organisation and leadership team. Our unique combination of cancer biology expertise and access to CRUK's world-class academic network, coupled with cutting edge technology platforms and clinical expertise enables us to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Key Responsibilities: A PhD in a relevant scientific discipline (or equivalent experience), preferably with up to 5 years of postdoctoral experience. Experience in a biotech or pharmaceutical setting is considered a plus.Prior hands-on experience with CRISPR screening modalities, particularly for target discovery. Exposure to advanced techniques (e.g., base editing, CRISPR activation, Perturb-seq, or combinatorial screening) is a strong advantage.Experience working with complex, disease-relevant cellular models (e.g., 3D/organoid cultures, primary immune cells) or in vivo systems.The ability to leverage bioinformatics datasets and genome/proteome-wide technologies, applying rigorous statistical thinking to large-scale biological data.Excellent communication skills, a collaborative mindset, and the ability to work effectively across cross-functional matrix teams.interested in applying and excited about working with us but are unsure if you have the right skills and experience,We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.You can explore our benefits by visiting our