Director Clinical Pharmacology

Director, Clinical Pharmacology

The Department of Clinical Pharmacology Modelling & Simulation Respiratory and Inflammation (CPMS R&I) at GSK is recruiting a director-level Clinical Pharmacologist.

This role is based in UK or US, with remote working or placement at other European GSK sites possible for the right candidate.

Job Purpose

The Director, Clinical Pharmacology sits within the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation, which aims to be a centre of excellence in Model Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging and mechanistic/systems modelling.

You will lead the end to end application of MIDD across the drug development lifecycle-from first in human studies through filing and lifecycle management-and provide clinical pharmacology strategy and evidence generation input. This is an opportunity to join a highly regarded, high impact team with a strong publication track record, reporting directly to the Respiratory, Immunology & Inflammation Research Unit (RIIRU).

Main Responsibilities

• Design & Execute Model Informed and Clinical Pharmacology strategies: Develop and implement robust MIDD & ClinPharm evidence strategies to de risk and accelerate RIIRU programs. Aim for faster development, optimal dosing and stronger regulatory positioning across respiratory, inflammation, neurodegeneration and emerging areas, and support business development opportunities.
• Ensure robust ways of working and regulatory ready evidence: Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling. Maintain up to date knowledge of FDA, EMA, CDE, PMDA and ICH expectations and embed regulatory considerations and best practices into study design and MIDD strategies.
• Build cross functional partnerships: Work closely with CPQM peers (digital medicine, translational imaging, MIDD specialists, mechanistic/systems modelling) and cross functional partners (biology, data science, computational biology, clinical, etc.). Maintain strong networks and share best practices in the CPMS community of practice. Build strong network key functions such as AI/ML, biomarkers, biostatistics, clinical operations, data science, computational biology and RWE to embed quantitative approaches into decision making at asset level.
• External engagement & scientific leadership: Raise GSK's profile in MIDD, clinical pharmacology, QSP and AI/ML integration through publications, conference presentations and active participation in scientific and regulatory fora to influence method adoption and regulatory dialogue.

Annual base salary for new hires in the United States ranges from $188,100 to $313,500, depending on location (Cambridge, MA; Waltham, MA; Rockville, MD; San Francisco, CA) and candidate qualifications. The position offers an annual bonus and eligibility to participate in GSK's share based long term incentive program, as well as health care and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

Basic Qualifications

• PhD in life sciences or related discipline, MD, or PharmD, with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and development.
• Significant experience in clinical pharmacology, modelling/simulation and drug development to solve practical problems in the pharmaceutical industry.
• Experience in pharmacometrics and their application to clinical questions in drug development.

Preferred Qualifications

• Additional experience in respiratory and immunology would be beneficial.
• Demonstrated experience of collaboration in a multi discipline team, using effective communication and taking personal accountability for timely delivery of results.
• Evidenced experience making sound judgement in complex situations and adapting to changing business needs by prioritizing multiple tasks.
• Experience working with senior stakeholders in a cross functional environment.
• Track record of implementation of Model Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs.
• Drive and learning agility to build knowledge on a drug disease system, symptom progression, standard of care, and trial design.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

If you require adjustments to our process to assist you in demonstrating your strengths and capabilities, please contact .