Senior Director, Translational Genetics

Overview

Senior Director, Translational Genetics. This role leads a team of translational genetics scientists within the GSK R&D Translational Sciences organization. The successful candidate provides strategic leadership, deep analytical expertise, and collaborates across functions to identify, develop, and deliver a portfolio of translational, data-driven work to accelerate delivery of the GSK portfolio. The team supports target assessments across priority therapeutic areas and addresses translational questions by integrating genetics with genomics (including proteomics) and clinical phenotypic data.

The candidate should have strong expertise in association genetics and experience applying statistical genetics approaches to translational questions. The role informs target discovery and validation, biomarker discovery and characterization, indication and patient subgroup selection, and advances understanding of disease pathobiology. The team works in a multidisciplinary, collaborative environment, interacting with GSK scientists and leaders to advance drug discovery and clinical development. The role also involves establishing external collaborations aligned with strategic priorities and opportunities for leadership development and excellence through impactful work.

Key Responsibilities

• Provide strategic leadership to set the direction of the team, ensuring alignment with evolving organizational priorities and delivering against timelines.
• Utilize expertise in genetic analysis and the integration of genetics with genomic (including proteomics) and clinical phenotypic data to address translational questions and generate disease-relevant, at-scale insights.
• Contribute hands-on analytical work to accelerate delivery of work packages impacting the GSK drug development pipeline.
• Lead cross-functional GSK project teams when appropriate, with emphasis on respiratory, hepatology, neurodegeneration, immunology, and/or renal disease.
• Identify, set up, and oversee externally aligned scientific collaborations.
• Communicate analysis findings clearly to project teams and senior leaders.
• Deliver personal and team outputs against objectives with strong statistical, analytical, and critical thinking within a translational context.
• Stay current with advances in translational genetics and the integration of genetics with genomics to address translational questions.
• Lead a team of direct reports and foster a culture of innovation, collaboration, and continuous professional learning.

Qualifications

• PhD or equivalent advanced degree in a relevant scientific discipline (e.g., statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics, or machine learning) with a track record of impactful publications and/or presentations.
• Experience in genetics analyses that integrate genetics, genomics, and/or clinical phenotypic data to inform drug discovery and development.
• Proven ability to work effectively in multidisciplinary teams and communicate complex concepts to diverse audiences.
• Advanced ability to identify and deliver innovative analytical solutions to address specific translational questions.
• Experience in developing and implementing new methodologies to integrate genetics and genomics in drug discovery and development.
• Experience in establishing and managing external collaborations to deliver impact for all parties.
• Ability to prioritize resources dynamically and align work with organizational priorities to maximize impact.
• Experience in leading and managing a high-performance team.
• Strong proficiency in at least one of R or Python, with a track record of writing reproducible, scalable code aligned with FAIR principles.
• Demonstrable understanding of stages of drug discovery and development.

Additional Information

Locations that may apply include Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA. Salary ranges and bonus eligibility reflect location and other factors. Benefits include health care, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. GSK is an Equal Opportunity Employer. Flexible/hybrid work options may be available.

If you require adjustments to the recruitment process, contact . For general information on compensation and benefits, details are provided in the recruitment materials. See the company's Equal Opportunity and non-discrimination statements in the job posting.