Protein Crystallographer

PE Global is currently recruiting for a Protein Crystallographer on behalf of a leading global biopharmaceutical organisation on a 12-month contract basis.

Based at a state-of-the-art research facility in Bracknell, this hybrid contract role will suit an experienced structural biologist with a strong background in protein crystallography and fragment-based ligand discovery (FBLD).

• Location: Bracknell, Berkshire
• Working Pattern: Hybrid (2 days per week on site)
• Rate: £28.54 - £38.01 per hour depending on experience.

Please note our client cannot assist with any visa sponsorship, and candidates must have the correct visa to live and work in UK for at least 12 months

Key Responsibilities

• Utilise low occupancy crystallography software and standard refinement packages to efficiently model and refine outputs from crystallographic fragment screening campaigns.
• Coordinate X ray data collection activities using internal synchrotron resources, external synchrotron facilities, and contract research organisations (CROs).
• Design, execute, and analyse fragment screening experiments using X ray crystallography.
• Collaborate with internal and external scientific partners to develop cutting edge crystallography methods, including approaches for identifying and characterising cryptic binding pockets.
• Support fragment progression through iterative design cycles, including fragment growth, linking, and merging strategies.
• Process and interpret large volumes of crystallographic datasets in parallel.
• Contribute to the continuous improvement of structural biology workflows, automation, and data quality standards.

Required Experience & Qualifications

• PhD in Structural Biology, Biochemistry, Chemical Biology, Chemistry, or a related scientific discipline.
• Significant hands on experience in protein crystallography, including solving large numbers of protein fragment crystal structures and processing extensive datasets in parallel.
• Demonstrable experience delivering fragment screening campaigns using X ray crystallography.
• Strong expertise with crystallography software including PHENIX and BUSTER.
• Experience using FBLD related software (Maestro/Schrödinger, ICM Pro, GINGER, FrankenROCS, Fragmentstein, cluster4x, PanDDA)
• Experience scripting and automating crystallography workflows, ideally within a High Performance Computing (HPC) environment.

Interested candidates should submit an updated CV. Please click the link below to apply.

Please note our client cannot assist with any visa sponsorship, and candidates must have the correct visa to live and work in UK